Embryonic camera-type eye formation

Across TCGA cell cohorts, RNA activity of the Embryonic camera-type eye formation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ADARB1, AKAP3, and MTERF3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ADARB1 grouped by Embryonic camera-type eye formation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ADARB1 →	-1.791	-0.888	.007	.007	3	4
BLOOD_Lymphoma	AKAP3 →	-0.647	-1.927	.006	<.001	3	4
BLOOD_Myeloma	MTERF3 →	+1.682	+1.512	<.001	.009	3	4
URINARY_TRACT	DNAJB2 →	-1.243	-1.853	.006	<.001	3	4
CNS	CCNC →	+0.316	+0.657	<.001	.005	3	3
CNS	NRP2 →	+2.072	+0.841	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ADARB1 by Embryonic camera-type eye formation activity — LUNG_SCLC

Explore this box plot interactively →