Embryonic camera-type eye formation

Across TCGA cell cohorts, RNA activity of the Embryonic camera-type eye formation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INPP4B, STK25, and TEKT3, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic camera-type eye formation activity versus INPP4B in LUNG_SCLC (Pearson r = 0.94).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	INPP4B →	+1.955	+1.927	<.001	.008	3	1
LUNG_SCLC	STK25 →	+0.730	+1.727	.001	.009	3	1
LUNG_SCLC	TEKT3 →	+0.235	+1.727	<.001	.009	3	1
LUNG_SCLC	MYBPC3 →	+0.110	+1.791	.008	.003	3	1
LUNG_SCLC	FGFBP2 →	+0.395	+1.927	<.001	.008	3	1
LUNG_SCLC	ATIC →	+0.509	+1.423	.006	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060900 vs INPP4B — LUNG_SCLC

Explore this scatter interactively →