Embryonic camera-type eye formation

Across TCGA cell cohorts, RNA activity of the Embryonic camera-type eye formation pathway is significantly associated with the total protein of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are HER2, HER3, and p27_pT198, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Embryonic camera-type eye formation activity versus HER2 in LUNG_SCLC (Pearson r = 0.88).

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HER2 →	+1.739	+1.644	.018	.011	2	1
LUNG_SCLC	HER3 →	+0.914	+1.644	.016	.011	2	1
LUNG_SCLC	p27_pT198 →	-0.391	-1.423	.013	.007	2	1
LUNG_SCLC	p27 →	+0.727	+1.644	.014	.011	2	1
LUNG_SCLC	p90 RSK →	+0.929	+1.644	.047	.011	2	1
LUNG_SCLC	AMPK_alpha →	+0.794	+1.644	.011	.011	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060900 vs HER2 — LUNG_SCLC

Explore this scatter interactively →