Neural plate regionalization

Across TCGA patient cohorts, RNA activity of the Neural plate regionalization pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARPC2, TRIM33, and MSN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural plate regionalization activity versus ARPC2 in BRCA (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ARPC2 →	-0.261	-0.072	<.001	<.001	3	6
LUAD	TRIM33 →	+0.180	+0.069	<.001	.004	3	6
LSCC	MSN →	-0.371	-0.121	<.001	<.001	3	6
HNSC	UNG →	+0.372	+0.102	<.001	<.001	3	6
BRCA	UQCC2 →	+0.373	+0.049	.001	.001	3	6
HNSC	NUP153 →	+0.123	+0.063	.004	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060897 vs ARPC2 — BRCA

Explore this scatter interactively →