Neural plate regionalization

Across TCGA patient cohorts, RNA activity of the Neural plate regionalization pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERBB4, CYP4X1, and CYBRD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural plate regionalization activity versus ERBB4 in CCRCC (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ERBB4 →	+0.676	+0.416	<.001	<.001	3	3
CCRCC	CYP4X1 →	+0.654	+0.494	.002	.004	3	3
CCRCC	CYBRD1 →	+0.663	+0.387	<.001	.004	3	3
BRCA	PGR →	+2.499	+0.445	<.001	<.001	3	3
LUAD	SPAG17 →	+0.761	+0.573	.001	.001	3	3
OV	PLA2G10 →	+0.595	+0.640	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060897 vs ERBB4 — CCRCC

Explore this scatter interactively →