Neural plate pattern specification

Across TCGA patient cohorts, RNA activity of the Neural plate pattern specification pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DYSF, RCOR3, and ZMYND8, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural plate pattern specification activity versus DYSF in LSCC (Pearson r = -0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DYSF →	-0.436	-0.067	<.001	<.001	3	8
LSCC	RCOR3 →	+0.412	+0.098	<.001	<.001	3	7
LSCC	ZMYND8 →	+0.309	+0.093	<.001	<.001	3	7
HNSC	ADNP →	+0.379	+0.108	<.001	<.001	3	7
LSCC	MYEF2 →	+0.702	+0.063	<.001	.001	3	7
BRCA	ZNF609_S491 →	+0.389	+0.057	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060896 vs DYSF — LSCC

Explore this scatter interactively →