Neural plate pattern specification

Across TCGA patient cohorts, RNA activity of the Neural plate pattern specification pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRMO, CCDC148, and DBIP2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural plate pattern specification activity versus TRMO in OV (Pearson r = 0.13).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TRMO →	+0.432	+0.739	.005	.001	3	3
LUAD	CCDC148 →	+0.474	+0.161	.006	.003	3	3
LUAD	DBIP2 →	+0.253	+0.118	.008	.009	3	3
BRCA	ACADSB →	+1.327	+0.492	.001	.003	3	3
PDAC	ENPP5 →	+0.575	+0.273	.004	.003	3	3
PDAC	C2orf74 →	+0.358	+0.315	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060896 vs TRMO — OV

Explore this scatter interactively →