Semicircular canal development

Across TCGA patient cohorts, RNA activity of the Semicircular canal development pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBX3, MEIS3, and DLG4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Semicircular canal development activity versus TBX3 in BRCA (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TBX3 →	+1.449	+0.519	<.001	<.001	3	7
BRCA	MEIS3 →	+0.867	+0.555	.007	<.001	3	6
OV	DLG4 →	+0.494	+0.208	.004	.004	3	6
PDAC	TGFB3 →	+0.915	+0.275	<.001	<.001	3	5
UCEC	TSHZ3 →	+0.902	+0.400	<.001	<.001	3	5
PDAC	C1QTNF6 →	+0.324	+0.179	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060872 vs TBX3 — BRCA

Explore this scatter interactively →