Semicircular canal development

Across TCGA cell cohorts, RNA activity of the Semicircular canal development pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GNL3, RGS11, and BMX, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GNL3 grouped by Semicircular canal development-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GNL3 →	-0.216	-0.939	.007	.007	3	5
BREAST	RGS11 →	-0.180	-1.103	<.001	<.001	3	4
BLOOD_Myeloma	BMX →	-0.288	-1.581	.002	<.001	3	3
PANCREAS	POLR3G →	-0.228	-1.158	.001	.007	3	3
LUNG_NSCLC_LUAD	CNNM1 →	+0.102	+0.692	<.001	.005	3	3
LARGE_INTESTINE	USP19 →	-0.182	-0.660	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GNL3 by Semicircular canal development activity — LUNG_SCLC

Explore this box plot interactively →