Venous blood vessel development

Across TCGA cell cohorts, RNA activity of the Venous blood vessel development pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SUN2, NXT2, and DHRS12, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Venous blood vessel development activity versus SUN2 in CNS (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SUN2 →	+0.901	+1.219	.002	.007	3	1
CNS	NXT2 →	+1.401	+1.551	.002	.001	3	1
CNS	DHRS12 →	+1.081	+1.817	.004	.001	3	1
CNS	ENG →	+2.212	+1.724	.008	.006	3	1
CNS	TYRP1 →	+2.352	+1.844	.004	.001	3	1
CNS	DDX58 →	+1.817	+1.315	.004	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060841 vs SUN2 — CNS

Explore this scatter interactively →