Regulation of canonical Wnt signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of canonical Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRORP, PCCB, and INHA, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of canonical Wnt signaling pathway activity versus PRORP in COAD (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PRORP →	-0.442	-1.162	<.001	<.001	3	1
COAD	PCCB →	-0.655	-0.831	.009	.008	3	1
COAD	INHA →	+0.520	+0.962	.005	.001	3	1
COAD	HABP4 →	+0.442	+1.123	.004	<.001	3	1
COAD	DYDC2 →	+1.230	+1.098	.009	.001	3	1
COAD	SLC39A4 →	+1.127	+1.168	.006	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060828 vs PRORP — COAD

Explore this scatter interactively →