Regulation of canonical Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of canonical Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZRANB1, WBP1L, and KHNYN, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of canonical Wnt signaling pathway activity versus ZRANB1 in BREAST (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZRANB1 →	+0.994	+0.037	.003	.003	3	14
OVARY	WBP1L →	+0.822	+0.030	<.001	.003	3	14
PANCREAS	KHNYN →	+1.112	+0.049	<.001	<.001	3	14
BLOOD_Leukemia	CTNND1 →	+1.557	+0.041	<.001	<.001	3	13
LUNG_NSCLC_LUSC	CDC42BPB →	+0.977	+0.038	.001	<.001	3	13
LARGE_INTESTINE	MTMR3 →	+0.835	+0.034	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060828 vs ZRANB1 — BREAST

Explore this scatter interactively →