Regulation of canonical Wnt signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of canonical Wnt signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC15A2, CAPZA2, and RAI14, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of canonical Wnt signaling pathway activity versus SLC15A2 in OESOPHAGUS (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SLC15A2 →	+1.164	+0.179	<.001	.002	3	7
OESOPHAGUS	CAPZA2 →	-1.732	-0.247	.002	<.001	3	6
BLOOD_Leukemia	RAI14 →	-1.583	-0.103	<.001	.009	3	6
STOMACH	PTK7 →	+4.851	+0.270	<.001	.006	3	5
BLOOD_Lymphoma	SLC19A2 →	-1.634	-0.158	<.001	.002	3	5
LUNG_SCLC	CLDN9 →	+1.711	+0.159	.003	<.001	2	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060828 vs SLC15A2 — OESOPHAGUS

Explore this scatter interactively →