Cell fate commitment involved in formation of primary germ layer

Across TCGA patient cohorts, RNA activity of the Cell fate commitment involved in formation of primary germ layer pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PIK3CG_S974, LYAR, and TRIM2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell fate commitment involved in formation of primary germ layer activity versus PIK3CG_S974 in UCEC (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PIK3CG_S974 →	-0.657	-0.102	<.001	<.001	3	6
LUAD	LYAR →	-0.234	-0.042	.001	.003	3	6
HNSC	TRIM2 →	+0.832	+0.089	<.001	<.001	3	5
COAD	FARP2 →	+0.148	+0.025	.007	.001	3	5
OV	CEP131 →	-0.423	-0.080	<.001	<.001	3	5
LUAD	KIAA1671 →	+0.330	+0.058	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060795 vs PIK3CG_S974 — UCEC

Explore this scatter interactively →