Cell fate commitment involved in formation of primary germ layer

Across TCGA patient cohorts, RNA activity of the Cell fate commitment involved in formation of primary germ layer pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EXO1, CHRNA5, and SKA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell fate commitment involved in formation of primary germ layer activity versus EXO1 in COAD (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EXO1 →	+0.599	+0.372	<.001	<.001	3	5
COAD	CHRNA5 →	+0.558	+0.478	<.001	<.001	3	5
LSCC	SKA1 →	+0.698	+0.272	<.001	.003	3	4
COAD	GFM2 →	+0.467	+0.551	.001	.002	3	4
CCRCC	IVD →	+0.384	+0.708	<.001	.002	3	4
CCRCC	DEPP1 →	-0.624	-0.734	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060795 vs EXO1 — COAD

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