Cell fate commitment involved in formation of primary germ layer

Across TCGA cell cohorts, RNA activity of the Cell fate commitment involved in formation of primary germ layer pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRORP, TFAP2A, and ZNF561, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRORP grouped by Cell fate commitment involved in formation of primary germ layer-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PRORP →	-0.740	-0.192	<.001	<.001	3	4
BREAST	TFAP2A →	-1.638	-0.176	<.001	.002	3	4
BREAST	ZNF561 →	-0.743	-0.176	<.001	.009	3	4
BREAST	PIGS →	-0.962	-0.230	.003	.002	3	4
CNS	SRP54 →	-0.411	-0.155	.001	.004	3	4
SKIN	TMEM184B →	-0.611	-0.158	.006	.008	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRORP by Cell fate commitment involved in formation of primary germ layer activity — BREAST

Explore this box plot interactively →