Negative regulation of androgen receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Negative regulation of androgen receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SFRP1, GUCY1A1, and SEPTIN11, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of androgen receptor signaling pathway activity versus SFRP1 in LSCC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SFRP1 →	+0.813	+0.049	<.001	<.001	3	8
HNSC	GUCY1A1 →	+0.377	+0.084	<.001	.002	3	8
BRCA	SEPTIN11 →	+0.470	+0.046	<.001	<.001	3	7
GBM	COL1A1 →	+0.960	+0.055	<.001	.004	3	7
GBM	COL1A2 →	+0.874	+0.064	<.001	.001	3	7
BRCA	GPX3 →	+0.742	+0.038	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060766 vs SFRP1 — LSCC

Explore this scatter interactively →