Negative regulation of androgen receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of androgen receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTTG1, NUDT5, and PCCB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTTG1 grouped by Negative regulation of androgen receptor signaling pathway-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PTTG1 →	-0.591	-0.865	.003	.002	3	4
BREAST	NUDT5 →	-0.553	-0.803	.003	.001	3	4
BLOOD_Myeloma	PCCB →	+0.849	+1.439	.006	.004	2	4
URINARY_TRACT	TRIAP1 →	+0.863	+1.271	.001	.004	3	3
URINARY_TRACT	FSCN2 →	+0.438	+1.271	.001	.004	3	3
URINARY_TRACT	TOPORS →	-0.713	-1.271	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTTG1 by Negative regulation of androgen receptor signaling pathway activity — CNS

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