Negative regulation of androgen receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of androgen receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are STON2, NCEH1, and DOCK5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of androgen receptor signaling pathway activity versus STON2 in OVARY (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	STON2 →	+2.410	+0.764	<.001	.004	3	6
OVARY	NCEH1 →	-1.681	-0.603	.001	.002	3	6
OVARY	DOCK5 →	-1.623	-0.590	<.001	.002	3	6
OVARY	FOSL1 →	-3.170	-0.717	.001	.003	3	6
CNS	SWSAP1 →	+0.446	+0.288	<.001	.009	3	6
BONE	PMP22 →	-5.090	-0.430	.004	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060766 vs STON2 — OVARY

Explore this scatter interactively →