Negative regulation of response to cytokine stimulus

Across TCGA patient cohorts, RNA activity of the Negative regulation of response to cytokine stimulus pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IFNG, KLHL23, and MEFV, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of response to cytokine stimulus activity versus IFNG in COAD (Pearson r = 0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	IFNG →	+0.870	+0.121	.004	.007	3	6
CCRCC	KLHL23 →	-0.703	-0.242	<.001	<.001	3	6
LSCC	MEFV →	+0.588	+0.132	<.001	<.001	3	5
GBM	HCST →	+0.633	+0.173	.002	.002	3	5
BRCA	THEMIS2 →	+0.746	+0.130	.001	.002	3	5
HNSC	IDO1 →	+1.500	+0.217	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060761 vs IFNG — COAD

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