Negative regulation of response to cytokine stimulus

Across TCGA cell cohorts, RNA activity of the Negative regulation of response to cytokine stimulus pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCSH, MICB, and ELP6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRKCSH grouped by Negative regulation of response to cytokine stimulus-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PRKCSH →	-0.750	-0.604	.005	.007	3	3
STOMACH	MICB →	-2.603	-0.157	.001	.008	3	3
BLOOD_Lymphoma	ELP6 →	-0.789	-1.620	.007	.007	2	4
BLOOD_Lymphoma	HDAC3 →	-0.606	-1.954	.009	<.001	3	3
BLOOD_Lymphoma	PALB2 →	-0.833	-1.976	.009	<.001	3	3
LARGE_INTESTINE	GATAD2A →	-0.677	-0.777	.001	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRKCSH by Negative regulation of response to cytokine stimulus activity — OVARY

Explore this box plot interactively →