Regulation of response to cytokine stimulus

Across TCGA patient cohorts, RNA activity of the Regulation of response to cytokine stimulus pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AIF1, RENBP, and RIN3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of response to cytokine stimulus activity versus AIF1 in GBM (Pearson r = 0.75).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AIF1 →	+0.968	+0.079	<.001	<.001	3	10
GBM	RENBP →	+0.585	+0.061	<.001	<.001	3	9
GBM	RIN3 →	+0.459	+0.065	<.001	<.001	3	9
GBM	SAMHD1 →	+0.429	+0.061	<.001	<.001	3	9
GBM	TNFAIP8L2 →	+0.688	+0.057	<.001	<.001	3	9
GBM	WIPF1 →	+0.408	+0.079	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060759 vs AIF1 — GBM

Explore this scatter interactively →