Parental behavior

Across TCGA patient cohorts, RNA activity of the Parental behavior pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MYO5A, FNBP1, and NR3C1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Parental behavior activity versus MYO5A in UCEC (Pearson r = 0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYO5A →	+0.265	+0.081	.005	.005	3	5
UCEC	FNBP1 →	+0.428	+0.116	.002	.004	3	4
UCEC	NR3C1 →	+0.419	+0.113	<.001	.007	3	4
UCEC	PLEKHA6 →	-0.360	-0.139	.003	<.001	3	4
UCEC	ARHGEF6 →	+0.413	+0.111	.001	.007	3	4
OV	RGS19_S65 →	+0.764	+0.118	.008	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060746 vs MYO5A — UCEC

Explore this scatter interactively →