Parental behavior

Across TCGA pan-cancer cohorts, RNA activity of the Parental behavior pathway is associated with patient survival in 24 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher Parental behavior pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as PAAD and LIHC, show the opposite pattern, with higher activity associated with better survival.

BLCA, MESO, and SCLC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.529	0.680	<.001	107	view →
MESO	OS	Median	All	0.282	0.495	.001	82	view →
SCLC	OS	Median	III,IV	0.446	0.767	.005	49	view →
PAAD	DFS	Median	All	0.396	0.176	.003	35	view →
SKCM	DFS	Quartile	All	0.498	0.767	.001	33	view →
UCEC	OS	Quartile	All	0.567	0.859	.003	32	view →
LIHC	OS	Quartile	All	0.773	0.564	.009	27	view →
LUSC	OS	Quartile	All	0.503	0.333	.006	20	view →
CESC	DFS	Tertile	All	0.810	0.647	.006	20	view →
UVM	DFS	Quartile	III,IV	0.268	1.000	.005	19	view →
LUAD	OS	Median	All	0.254	0.452	<.001	17	view →
LGG	DFS	Median	All	0.654	0.793	.004	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

GO:0060746–BLCA (OS)

Open the BLCA breakdown →