Parental behavior

Across TCGA patient cohorts, RNA activity of the Parental behavior pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NR3C1, TRAV13-2, and PRKCB, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Parental behavior activity versus NR3C1 in CCRCC (Pearson r = -0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	NR3C1 →	+0.579	+0.535	<.001	<.001	3	5
UCEC	TRAV13-2 →	+0.626	+0.498	.009	.008	3	4
BRCA	PRKCB →	+0.653	+0.624	<.001	<.001	3	3
BRCA	SLC8A1 →	+0.240	+0.381	.001	.003	3	3
UCEC	TRBJ2-3 →	+1.588	+0.646	<.001	<.001	3	3
HNSC	SIRPB3P →	+0.283	+0.646	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060746 vs NR3C1 — CCRCC

Explore this scatter interactively →