Parental behavior

Across TCGA cell cohorts, RNA activity of the Parental behavior pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TUBGCP4, UBE2L6, and ISG15, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TUBGCP4 grouped by Parental behavior-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TUBGCP4 →	+0.801	+1.335	.001	.001	3	3
PANCREAS	UBE2L6 →	+1.379	+1.156	.005	.003	3	3
PANCREAS	ISG15 →	+1.553	+1.529	.007	<.001	3	3
SOFT_TISSUE	EMP2 →	+1.651	+1.085	.001	.002	3	3
BLOOD_Leukemia	BST2 →	+2.201	+0.656	.001	.003	3	3
BLOOD_Leukemia	ADSS1 →	+1.993	+1.080	.008	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TUBGCP4 by Parental behavior activity — PANCREAS

Explore this box plot interactively →