Prostate gland growth

Across TCGA cell cohorts, RNA activity of the Prostate gland growth pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPAN9, CYP27A1, and RPS3A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSPAN9 grouped by Prostate gland growth-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TSPAN9 →	-1.473	-0.978	.001	.009	3	4
PANCREAS	CYP27A1 →	+1.319	+1.304	.001	<.001	2	5
LARGE_INTESTINE	RPS3A →	-0.692	-1.421	.001	<.001	3	4
BLOOD_Leukemia	TRIM38 →	+0.847	+0.928	<.001	.005	3	4
URINARY_TRACT	NNT →	+1.609	+1.863	.006	<.001	3	4
CNS	B2M →	+0.965	+0.763	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSPAN9 by Prostate gland growth activity — PANCREAS

Explore this box plot interactively →