Positive regulation of inositol phosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of inositol phosphate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SF3B1, XPO1, and NONO, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of inositol phosphate biosynthetic process activity versus SF3B1 in GBM (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SF3B1 →	-0.209	-0.078	<.001	<.001	3	9
LSCC	XPO1 →	-0.182	-0.056	<.001	<.001	3	8
GBM	NONO →	-0.205	-0.095	<.001	<.001	3	8
OV	RIN3 →	+0.559	+0.062	<.001	<.001	3	8
OV	DHX9 →	-0.318	-0.077	<.001	<.001	3	8
GBM	STAG2 →	-0.297	-0.063	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060732 vs SF3B1 — GBM

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