Positive regulation of inositol phosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of inositol phosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF646, SMUG1, and COQ10A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZNF646 grouped by Positive regulation of inositol phosphate biosynthetic process-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	ZNF646 →	-0.840	-0.519	.008	.007	3	4
LARGE_INTESTINE	SMUG1 →	+0.366	+0.680	.009	.009	3	3
LARGE_INTESTINE	COQ10A →	+1.145	+1.259	<.001	<.001	3	3
LARGE_INTESTINE	NOSTRIN →	-1.256	-0.908	.009	.002	3	3
LARGE_INTESTINE	DNAJB7 →	+0.185	+0.904	.009	.005	3	3
LARGE_INTESTINE	CSTF2T →	+0.666	+0.838	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZNF646 by Positive regulation of inositol phosphate biosynthetic process activity — BLOOD_Lymphoma

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