Intestinal epithelial structure maintenance

Across TCGA patient cohorts, RNA activity of the Intestinal epithelial structure maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LCP2, CORO1A, and RCSD1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intestinal epithelial structure maintenance activity versus LCP2 in HNSC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LCP2 →	+0.513	+0.073	<.001	.001	3	8
GBM	CORO1A →	+0.419	+0.051	<.001	<.001	3	7
HNSC	RCSD1 →	+0.387	+0.048	<.001	.004	3	6
HNSC	SASH3 →	+0.363	+0.057	.001	.009	3	6
GBM	SKAP2 →	+0.523	+0.063	<.001	<.001	3	6
OV	STK10_S514 →	+0.661	+0.042	.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060729 vs LCP2 — HNSC

Explore this scatter interactively →