Intestinal epithelial structure maintenance

Across TCGA patient cohorts, RNA activity of the Intestinal epithelial structure maintenance pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HAUS1, ZNF486, and INTS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intestinal epithelial structure maintenance activity versus HAUS1 in LSCC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HAUS1 →	+0.621	+0.529	<.001	.008	3	4
LSCC	ZNF486 →	+0.781	+0.566	.001	<.001	3	4
BRCA	INTS2 →	+0.483	+0.790	.003	.001	3	4
BRCA	TTLL5 →	+0.339	+0.873	.001	<.001	3	4
GBM	LRRC75A →	+0.552	+0.887	<.001	<.001	3	4
GBM	MAFG-DT →	+0.345	+0.790	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060729 vs HAUS1 — LSCC

Explore this scatter interactively →