Intestinal epithelial structure maintenance

Across TCGA cell cohorts, RNA activity of the Intestinal epithelial structure maintenance pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR45B, ZNF195, and ADGRD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR45B grouped by Intestinal epithelial structure maintenance-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	WDR45B →	+0.476	+0.824	.006	.003	3	3
LUNG_SCLC	ZNF195 →	+1.064	+0.918	<.001	.007	3	3
LIVER	ADGRD1 →	+2.686	+1.576	.005	.003	3	3
LIVER	STAC →	-3.864	-1.856	<.001	.003	3	3
LIVER	MPZL2 →	+2.549	+1.556	.008	<.001	3	3
LIVER	BTBD11 →	-1.765	-2.064	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR45B by Intestinal epithelial structure maintenance activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →