Chorion development

Across TCGA patient cohorts, RNA activity of the Chorion development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, KIF22, and KIF23, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chorion development activity versus SMC2 in GBM (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SMC2 →	+0.500	+0.055	<.001	<.001	3	8
LSCC	KIF22 →	+0.460	+0.074	<.001	<.001	3	8
COAD	KIF23 →	+0.688	+0.044	<.001	.003	3	8
GBM	NASP →	+0.480	+0.058	<.001	<.001	3	8
UCEC	SMC4 →	+0.704	+0.095	<.001	<.001	3	7
LSCC	TAF4 →	+0.152	+0.043	.008	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060717 vs SMC2 — GBM

Explore this scatter interactively →