Labyrinthine layer blood vessel development

Across TCGA cell cohorts, RNA activity of the Labyrinthine layer blood vessel development pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDLRAP1, GMDS, and LAMC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LDLRAP1 grouped by Labyrinthine layer blood vessel development-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	LDLRAP1 →	+0.847	+0.640	.001	.008	3	5
STOMACH	GMDS →	+1.995	+1.561	.009	.006	3	4
STOMACH	LAMC2 →	+3.723	+1.970	<.001	<.001	3	4
BLOOD_Lymphoma	TRPT1 →	-1.031	-2.212	.001	<.001	3	4
PANCREAS	ANAPC5 →	-0.684	-1.275	.002	.001	3	4
SOFT_TISSUE	POP5 →	-0.595	-1.571	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LDLRAP1 by Labyrinthine layer blood vessel development activity — BREAST

Explore this box plot interactively →