Labyrinthine layer development

Across TCGA patient cohorts, RNA activity of the Labyrinthine layer development pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CENPF, TOP2A, and CCNB1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Labyrinthine layer development activity versus CENPF in PDAC (Pearson r = 0.10).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CENPF →	+0.606	+0.216	.001	<.001	3	4
LUAD	TOP2A →	+0.629	+0.109	.008	.001	3	4
PDAC	CCNB1 →	+0.685	+0.260	<.001	<.001	3	4
PDAC	KIF2C →	+0.618	+0.224	<.001	<.001	3	4
GBM	CAMK4 →	-0.928	-0.153	<.001	<.001	3	4
GBM	JPH4 →	-1.347	-0.194	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060711 vs CENPF — PDAC

Explore this scatter interactively →