Trophoblast giant cell differentiation

Across TCGA patient cohorts, RNA activity of the Trophoblast giant cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WFS1, IRGQ, and NAT14, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Trophoblast giant cell differentiation activity versus WFS1 in BRCA (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	WFS1 →	-0.941	-0.404	.001	.001	3	3
BRCA	IRGQ →	-0.276	-0.326	.006	.009	3	3
LSCC	NAT14 →	-0.582	-0.351	.005	.003	3	3
PDAC	DRAM2 →	-0.248	-0.443	<.001	.002	3	2
PDAC	PPIAP86 →	+0.058	+0.621	.003	.002	3	2
PDAC	RPL23AP26 →	-0.056	-0.678	.005	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060707 vs WFS1 — BRCA

Explore this scatter interactively →