Cell differentiation involved in embryonic placenta development

Across TCGA patient cohorts, RNA activity of the Cell differentiation involved in embryonic placenta development pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT8, KRT19, and KRT18, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cell differentiation involved in embryonic placenta development activity versus KRT8 in CCRCC (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KRT8 →	+0.871	+0.661	.006	<.001	3	9
CCRCC	KRT19 →	+2.063	+0.501	<.001	.003	2	7
BRCA	KRT18 →	+1.010	+0.433	<.001	<.001	3	6
BRCA	SPINT1 →	+0.739	+0.505	<.001	<.001	3	5
CCRCC	SCNN1A →	+1.693	+0.813	<.001	<.001	3	5
CCRCC	MAL2 →	+1.061	+0.563	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060706 vs KRT8 — CCRCC

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