Regulation of ribonuclease activity

Across TCGA patient cohorts, RNA activity of the Regulation of ribonuclease activity pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMA2, FAM83D, and ASF1B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of ribonuclease activity activity versus LAMA2 in HNSC (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LAMA2 →	-0.904	-0.198	.001	<.001	3	6
LUAD	FAM83D →	+0.986	+0.257	<.001	<.001	3	6
BRCA	ASF1B →	+0.747	+0.262	.002	.001	3	6
BRCA	E2F8 →	+0.858	+0.261	.001	<.001	3	6
LUAD	LMNB1 →	+0.706	+0.266	<.001	<.001	3	5
BRCA	MKI67 →	+1.094	+0.336	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060700 vs LAMA2 — HNSC

Explore this scatter interactively →