Regulation of morphogenesis of a branching structure

Across TCGA patient cohorts, RNA activity of the Regulation of morphogenesis of a branching structure pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KANK2, LARP1, and NCAPG_S674, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of morphogenesis of a branching structure activity versus KANK2 in BRCA (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	KANK2 →	+0.583	+0.038	<.001	<.001	3	7
COAD	LARP1 →	-0.211	-0.018	.006	.004	3	6
PDAC	NCAPG_S674 →	-0.681	-0.034	<.001	<.001	3	6
BRCA	TAGLN_S166 →	+0.488	+0.028	.004	.002	3	6
LUAD	DIAPH1 →	-0.261	-0.041	<.001	<.001	3	6
HNSC	IGFBP5 →	+0.612	+0.068	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060688 vs KANK2 — BRCA

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