Regulation of branching involved in prostate gland morphogenesis

pathway activity — cross-omics
GO:0060687Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of branching involved in prostate gland morphogenesis pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MINDY1, ZNF695, and CENPW, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAMINDY1 →+0.833+0.258<.001<.00133
OVZNF695 →-0.644-0.751.005<.00133
OVCENPW →-1.809-1.032<.001<.00133
BRCAC1orf220 →+0.562+0.209.005.00633
BRCACCDC28A →+0.785+0.377.001.00633
BRCAZKSCAN2-DT →+0.756+0.212<.001.00533
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration