Ureteric bud elongation

Across TCGA patient cohorts, RNA activity of the Ureteric bud elongation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EXOSC8, SMCHD1, and DDX21_S71, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ureteric bud elongation activity versus EXOSC8 in GBM (Pearson r = -0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EXOSC8 →	-0.269	-0.058	.001	.005	3	6
BRCA	SMCHD1 →	-0.330	-0.046	.004	.002	3	6
BRCA	DDX21_S71 →	-1.033	-0.046	.001	.002	2	6
OV	ANG →	+0.441	+0.074	.008	<.001	3	5
LUAD	ATP9A →	+0.443	+0.078	<.001	<.001	3	5
BRCA	ACTL6A →	-0.267	-0.044	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060677 vs EXOSC8 — GBM

Explore this scatter interactively →