Ureteric bud elongation

Across TCGA patient cohorts, RNA activity of the Ureteric bud elongation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPRY2, MAL, and RPL32P26, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ureteric bud elongation activity versus SPRY2 in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SPRY2 →	+0.723	+0.517	.001	.005	3	4
UCEC	MAL →	-1.161	-0.219	.001	.003	3	4
LUAD	RPL32P26 →	+0.339	+0.196	.007	.001	3	3
LUAD	MIR3125 →	+0.658	+0.194	<.001	.003	3	3
BRCA	GRM7-AS1 →	+0.166	+0.559	.002	.002	3	3
BRCA	TNFSF12 →	+0.586	+0.514	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060677 vs SPRY2 — BRCA

Explore this scatter interactively →