Ureteric bud elongation

Across TCGA cell cohorts, RNA activity of the Ureteric bud elongation pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAPGEF5, CSK, and GEN1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAPGEF5 grouped by Ureteric bud elongation-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RAPGEF5 →	+0.240	+1.096	<.001	<.001	3	4
OVARY	CSK →	-0.228	-1.147	.003	.001	3	3
URINARY_TRACT	GEN1 →	+0.135	+1.543	.003	.005	3	3
LARGE_INTESTINE	TAOK1 →	-0.199	-0.170	<.001	<.001	3	3
SOFT_TISSUE	ITIH5 →	+0.195	+1.168	<.001	<.001	3	3
SOFT_TISSUE	RNPEP →	-0.276	-1.021	.002	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAPGEF5 by Ureteric bud elongation activity — SKIN

Explore this box plot interactively →