Ureteric bud formation

Across TCGA patient cohorts, RNA activity of the Ureteric bud formation pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ECE1, SIX1_S204, and NMT1_S73, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ureteric bud formation activity versus ECE1 in COAD (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ECE1 →	+0.177	+0.082	.001	.001	3	6
LUAD	SIX1_S204 →	+1.324	+0.169	.001	<.001	3	5
LUAD	NMT1_S73 →	+0.356	+0.081	.005	.006	3	5
LUAD	CDC42EP1_S353 →	-0.585	-0.131	.002	<.001	3	5
LUAD	DNAAF2 →	+0.165	+0.079	.004	.005	3	5
GBM	KSR1_T288 →	+0.265	+0.081	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060676 vs ECE1 — COAD

Explore this scatter interactively →