Ureteric bud formation

Across TCGA patient cohorts, RNA activity of the Ureteric bud formation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POPDC2, MYL9, and CNN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ureteric bud formation activity versus POPDC2 in COAD (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	POPDC2 →	+0.862	+0.303	<.001	<.001	3	4
COAD	MYL9 →	+1.029	+0.237	.001	.009	3	4
COAD	CNN1 →	+1.564	+0.282	<.001	.001	3	4
COAD	DPT →	+0.730	+0.178	.007	.003	3	4
BRCA	ADAMTSL3 →	+0.712	+0.817	<.001	<.001	3	4
BRCA	NEGR1 →	+0.904	+0.702	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060676 vs POPDC2 — COAD

Explore this scatter interactively →