Ureteric bud formation

Across TCGA cell cohorts, RNA activity of the Ureteric bud formation pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XKR6, PLOD3, and SWAP70, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, XKR6 grouped by Ureteric bud formation-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	XKR6 →	+1.620	+0.265	.002	.009	3	4
BLOOD_Myeloma	PLOD3 →	-0.912	-0.478	.004	<.001	3	3
SKIN	SWAP70 →	-0.992	-1.286	.002	<.001	3	3
SKIN	SDCBP →	-1.460	-0.938	.001	.003	3	3
SKIN	JAZF1 →	-1.633	-1.458	.001	<.001	3	3
LARGE_INTESTINE	ESRP2 →	-1.196	-0.363	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

XKR6 by Ureteric bud formation activity — LIVER

Explore this box plot interactively →