Ureteric bud formation

Across TCGA cell cohorts, RNA activity of the Ureteric bud formation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR19, PGAP1, and SH2B1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR19 grouped by Ureteric bud formation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	WDR19 →	-0.144	-1.103	<.001	.001	3	4
BREAST	PGAP1 →	+0.156	+0.914	<.001	.004	3	4
UPPER_AERODIGESTIVE_TRACT	SH2B1 →	-0.183	-0.244	.006	.007	3	4
LIVER	KCNG3 →	+0.214	+1.590	.001	<.001	3	4
CNS	PHYKPL →	-0.095	-1.203	.002	.001	3	4
CNS	NCOA1 →	+0.163	+1.016	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR19 by Ureteric bud formation activity — BREAST

Explore this box plot interactively →