Mammary gland epithelial cell differentiation

Across TCGA cell cohorts, RNA activity of the Mammary gland epithelial cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C22orf31, PLEK2, and TM9SF4, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mammary gland epithelial cell differentiation activity versus C22orf31 in LARGE_INTESTINE (Pearson r = -0.97).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C22orf31 →	-0.105	-0.650	.002	.002	3	1
LARGE_INTESTINE	PLEK2 →	+1.159	+0.526	.006	.005	3	1
LARGE_INTESTINE	TM9SF4 →	-0.882	-0.543	<.001	.002	3	1
LARGE_INTESTINE	NRF1 →	-0.439	-0.543	.004	.002	3	1
LARGE_INTESTINE	NUP98 →	-0.667	-0.543	.003	.002	3	1
LARGE_INTESTINE	TENT4A →	-1.235	-0.699	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060644 vs C22orf31 — LARGE_INTESTINE

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