Regulation of microtubule-based movement

Across TCGA cell cohorts, RNA activity of the Regulation of microtubule-based movement pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RTP4, APOL1, and TRIM38, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microtubule-based movement activity versus RTP4 in CNS (Pearson r = -0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	RTP4 →	-1.540	-0.053	<.001	.002	3	10
STOMACH	APOL1 →	-2.657	-0.080	<.001	<.001	3	9
STOMACH	TRIM38 →	-1.345	-0.105	.001	<.001	3	9
LUNG_SCLC	HLA-B →	-3.253	-0.078	.001	.007	3	9
BONE	ZNFX1 →	-0.963	-0.077	<.001	.003	3	9
STOMACH	EPAS1 →	-3.161	-0.096	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060632 vs RTP4 — CNS

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