Regulation of microtubule-based movement

Across TCGA cell cohorts, RNA activity of the Regulation of microtubule-based movement pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPTBN2, PRUNE1, and NDUFS3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microtubule-based movement activity versus SPTBN2 in OESOPHAGUS (Pearson r = -0.34).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SPTBN2 →	-1.931	-0.207	.003	.003	2	5
UPPER_AERODIGESTIVE_TRACT	PRUNE1 →	-0.681	-0.266	.008	<.001	2	5
BREAST	NDUFS3 →	-0.758	-0.671	.007	.007	3	4
PANCREAS	POLR1C →	-0.754	-0.246	.001	.001	3	4
PANCREAS	ZNF408 →	-0.622	-0.266	.005	.002	3	4
KIDNEY	CCNJL →	-0.751	-0.133	.003	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060632 vs SPTBN2 — OESOPHAGUS

Explore this scatter interactively →